General description
The analytes in this panel include key markers of apoptosis (e.g., Cleaved PARP, CHOP), autophagy (LC3B), DNA damage (Phospho-Histone H2A.x), cell proliferation (Ki67), and stress response (HSP70, GRP78), providing a comprehensive snapshot of cellular health. These biomarkers are critical for monitoring cellular responses to drug treatment, environmental stress, and disease progression, making the panel ideal for toxicology studies, cancer research, and pathway analysis. Their multiplexed detection enables efficient profiling of multiple pathways from limited sample volumes.
Application
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze 16 analytes in cell lysate samples to support pathway analysis and enhance the reliability of comparative protein expression studies.
Analytes Included: CHOP, Cyclin B1, Complex IV, Ki67, LC3B, HIF-1α, Polyubiquitin (K48-linkage), HSP70, Cleaved PARP, GRP78, Phospho-eIF4B (Ser422), Phospho-NF-κB (Ser536), Phospho-Histone H2A.x (Ser139), Phospho-Histone H3 (Ser10), Phospho-p53 (Ser15), Phospho-RNA Pol II (Ser2)
Assay Characteristics: Refer to the assay protocol for details on cross-reactivity, buffer compatibility, lysate control, and recommended loading control (MAPmate™ Control Assays).
Features and Benefits
Simultaneously measures 16 key markers of cell health in a single assay
Covers apoptosis, autophagy, DNA damage, proliferation, and stress response pathways
Ideal for studying cellular responses to drug treatment, disease, and environmental stress
High sensitivity and reproducibility using Luminex® xMAP® technology
Suitable for limited sample volumes and high-throughput analysis
Legal Information
Luminex is a registered trademark of Luminex Corporation
MAPMATE is a trademark of Merck KGaA, Darmstadt, Germany
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Disclaimer
For research use only. Not for use in diagnostic procedures.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
