Merck, 14-842, Lck Protein, activated, 10 µg
Size:10 μg, activated, N-terminal 6His-tagged, recombinant, human Lck full length, for use in Kinase Assays.
Available Catalog Numbers
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| UNSPSC Code | 12352202 |
|---|---|
| NACRES | NA.41 |
| eCl@ss | 32160405 |
| Quality Level | 100 |
| biological source | human |
| product line | Upstate® |
| specific activity | (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.) |
| mol wt | Mw 59 kDa |
| purified by | (Ni2+/NTA-agarose) |
| species reactivity | human |
| manufacturer/tradename | Upstate® |
| technique(s) | activity assay: suitable (kinase) |
| accession no. | (FUNCTION: SwissProt: P06239 # Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyp) |
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| NCBI accession no. | NM_005356.3 |
|---|
| recombinant | expressed in baculovirus infected Sf21 cells |
|---|
| UniProt accession no. | P06239 |
|---|
| relevant disease(s) | obesity; metabolic disorders |
|---|
