Merck, 14-439, MAP Kinase 1/Erk1 Protein, active, 10 µg

General description
Research area: Cell Signaling

Recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag
Biochem/physiol Actions
Extracellular-signal-regulated kinase 1 (ERK1)/ Extracellular-signal-regulated kinase 2 (ERK2), as part of the Ras-Raf-MEK-ERK signal transduction cascade, are involved in regulating a wide range of cellular processes, including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcriptional control. Additionally, ERK1 signaling contributes to the regulation of cyclin D1 expression during the cell cycle. MAP kinases play a crucial role in inflammation and immune responses by regulating the production of pro- and anti-inflammatory cytokines, as well as prostaglandins, in response to lipopolysaccharide (LPS) stimulation.
Packaging
Also available in 250μg size as catalog # 14-439M - Call for pricing and availability.
Physical form
Purified by glutathione-agarose. Activated with MEK1 and repurified on Ni2+/NTA agarose
Analysis Note
routinely evaluated by phosphorylation of MBP
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany