Merck, 14-404, ZAP-70 Protein, active, 20 µg

General description
Research area: CELL SIGNALING

Product Source: expressed in Sf21 Recombinant, human, full length ZAP-70 containing a C-terminal His6-tag

Zeta-chain-associated protein kinase 70 (ZAP-70) is a cytoplasmic tyrosine kinase that consists of tandem SH2 (tSH2) domains at the beginning, linked with a long linker region, and a tyrosine kinase domain at the C-terminal end.
Biochem/physiol Actions
Protein Target: ZAP-70

Target Sub-Family: TK

Zeta-chain-associated protein kinase 70 (ZAP-70) plays a vital role in the development and function of T cells and natural killer cells. It interacts directly with the activated T-cell receptor and regulates downstream signals. In addition, ZAP-70 also mediates B-cell receptor (BCR) signaling. Mutations in ZAP-70 have been associated with severe combined immunodeficiency (SCID), chronic lymphocytic leukemia (CLL) , and the development of autoreactive T cells that attack the joints.
Physical form
Ni²⁺/NTA-agarose
Preparation Note
6 months at -20C
Analysis Note
routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1) substrate peptide
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.