Merck, 14-347, CHK2 Protein, active, 10 µg
Size:10 μg, Active, recombinant human CHK2, residues 5-543, containing N-terminal GST & C-terminal His-6 tags, for use in Kinase Assays.
Available Catalog Numbers
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| UNSPSC Code | 12352202 |
|---|---|
| NACRES | NA.32 |
| eCl@ss | 32160405 |
| biological source | human |
| Quality Level | 100 |
| Gene Information | human ... CHEK2(11200) |
| product line | Upstate® |
| specific activity | (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.) |
| mol wt | Mw 89.6 kDa |
| purified by | (glutathione-agarose and Ni2+/NTA-agarose) |
| species reactivity | human |
| manufacturer/tradename | Upstate® |
| technique(s) | activity assay: suitable (kinase) |
| accession no. | (FUNCTION: SwissProt: O96017 # Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on ′Ser-216′, preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at ′Thr-18′ and ′Ser-20′. ) |
| NCBI accession no. | NM_001005735.1 |
| recombinant | expressed in E. coli |
| UniProt accession no. | O96017 |
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