| UNSPSC Code | 12352202 |
|---|---|
| NACRES | NA.32 |
| eCl@ss | 32160405 |
| biological source | human |
| Quality Level | 100 |
| Gene Information | human ... PRKAA2(5563), PRKAB1(5563) |
| product line | Upstate® |
| specific activity | (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.) |
| mol wt | Mw 30 kDa (AMPKβ1) |
| purified by | (Ni2+/NTA-agarose) |
| species reactivity | human |
| manufacturer/tradename | Upstate® |
| technique(s) | activity assay: suitable (kinase) |
| accession no. | (Function: Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5′-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit. ) |
| NCBI accession no. | NM_002733 |
| UniProt accession no. |
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| P54619 |
| relevant disease(s) | diabetes; obesity; metabolic disorders |
|---|
| recombinant | expressed in E. coli |
|---|
