Merck, 14-814, UbcH8 Conjugating Enzyme, 100 µg

General description
UbcH8 is a class I ubiquitin-conjugating (E2) enzyme highly similar in structure to UbcH7. UbcH8 is a primary target gene of interferon-alpha and gamma, and recent studies have indicated that UbcH8 is the E2 enzyme for the ubiquitin-like protein ISG15. These studies suggest overlap between the ISG15 and ubiquitin conjugation pathways, and have important implications for understanding the regulation and function of ISG15 in the IFN alpha/beta response. Typical enzyme concentration to support conjugation in vitro is 100nM to 1μM depending upon conditions.
expressed in E. coli
Application
UbcH8 is a class I ubiquitin-conjugating (E2) enzyme highly similar in structure to UbcH7. UbcH8 is a primary target gene of interferon-alpha & gamma.
Physical form
Format: Purified using Ni²⁺ chelation chromatography with Ni2+ in limiting concentration.
Preparation Note
For long term storage store at -80°C.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
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