Merck, 14-916M, PEK, active

General description
71 kDa
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1)
Packaging
Also available in 10μg size as catalog # 14-916 and in 250 μg as catalog # 14-916-K.
Physical form
Protein in of 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution
Preparation Note
6 months at -70°C
Analysis Note
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Routinely evaluated by phosphorylation of the peptide RSRSRSRSRSRSRSR
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.