Merck, 14-1067, Human Recombinant MeCP2 (methyl-CpG-binding protein 2)

General description
Human recombinant N-terminal His-tagged MeCP2 expressed in SF9 insect cells and purified by Fast Protein Liquid Chromatography (FPLC).
MeCP2 (methyl-CpG-binding protein 2) binds methylated CpG sequences in double-stranded DNA resulting in the suppression of transcription. This protein is likely to be involved in the repression of multiple genes. Consistent with this role, mutations of MeCP2 are linked to Rett syndrome, a progressive neurological disorder that is one of the most common causes of mental retardation in females.
Application
Research Category
Epigenetics & Nuclear Function
Physical form
In a buffer containing 20 mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 M NaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT.
Preparation Note
Stable at -80ºC for 6 months from date of receipt.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.