Description
General description
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates.[Saridakis, 2005] Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, Ubiquitin carboxyl-terminal hydrolase 7 activity generally stabilizes its substrate proteins. Ubiquitin carboxyl-terminal hydrolase 7 is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53.[Canning, 2004]
~ 128kDa Observed
Immunogen
Histadine-tagged recombinant protein corresponding to human USP7.
Application
This Anti-USP7 Antibody, clone 1G7 is validated for use in WB, IP, IH for the detection of USP7.
Biochem/physiol Actions
This antibody recognizes USP7.
Physical form
Format: Purified
Analysis Note
Evaluated by Western Blot in HeLa lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected USP7 on 10 µg of HeLa cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.