Merck, 05-1938, Anti-G3BP1 Antibody, clone 14E5-G9

General description
G3BP1 (Ras-GTPase activating protein SH3-domain binding protein 1) directly associates with SH3 domains of GTPase activating proteins (GAPs). It was first discovered by its binding to RasGAP. G3BPs have been shown to be involved in a number of mitogenic signaling pathways. G3BP1 is also known to be over expressed in many human cancers (Kim, 2007) and its expression appears to be inversely correlated with PTEN expression (Kim, 2007). Interestingly, G3BP1, along with G3BP2, has been shown to bind to the C-terminus of p53, playing a crucial role in its activity (Kim, 2007). Furthermore, the G3BPs have two traditional RNA binding motifs.
52 kDa
Immunogen
GST-tagged recombinant protein corresponding to human G3BP1.
Application
Anti-G3BP1 Antibody, clone 14E5-G9 is an antibody against G3BP1 for use in WB & IC.
Research Sub Category
RNA Metabolism & Binding Proteins

G-proteins
Biochem/physiol Actions
This antibody recognizes G3BP1.
Physical form
Format: Purified
Analysis Note
Evaluated by Western Blot in K562 cell lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected G3BP1 on K562 cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.